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KMID : 0382619880080010487
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Hanyang Journal of Medicine
1988 Volume.8 No. 1 p.487 ~ p.496
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Electrophysiological Effect of Tannic Acid on the Sinoatrial Node and Atrial Muscle Cells of the Rabbit Heart
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Abstract
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Though several workers have demonstrated that intravenous administration of
tannic acid elicits a hypotensive response, little study has been made on the direct
action of tannin on the heart. Therefore the present study was undertaken to in-
vestigate direct effects of tannic acid on the sinoatrial node and atrial muscle cells
,I of the rabbit heart by means of conventional microelectrode techniques.
A superfusion of sinus node cells with tannic acid (0.1, 0.25, 0.510) resulted in a
. concentration-dependent reduction of action potential amplitude (APA) and rate of
spontaneous firing (RSF), and t upstroke velocity)was also decreased
aX(maximum
.:. by 0.25% tannic acid but action potential duration (APD) was not altered significantly.
` i Following superfusion of atrial muscle cell respectively with 0.1% tannic acid (pH
5.8) and acid-Tyrode solution (pH 5.8), APA and RSF were generally decreased. The
effects on APA and RSF of tannin was far more pronounced than that of acid-Tyrode
i ´ solution. A significant prolongation of APD was observed only after superfusion of
atrial muscle fiber with acid-Tyrode solution.
The results of present study suggest that tannic acid can exert direct effects on
the sinus node and atrial muscle cells generally decreasing APA and RSF.
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